Advancing Oral Drug Delivery of BCS Class II Drugs Using Solid Lipid Nanoparticles
Keywords:
Bioavailability, biopharmaceutics classification system class II drugs, solid lipid nanoparticlesAbstract
In drug discovery, approximately 70% of new drug candidates have shown poor aqueous solubilityin recent years. Currently, approximately 40% of the marketed immediate release (IR) oral drugs arecategorized as practically insoluble (<100 g/mL). The aqueous solubility of a drug is a critical determinantof its dissolution rate. The Biopharmaceutics Classification System (BCS) is a useful tool for decision making in formulation development from a biopharmaceutical point of view
References
1. Ku MS, Dulin W. A biopharmaceutical classificationbased right-first-time formulation approach to reduce human pharmacokinetic variability and project cycle time from first-in-human to clinical proof-of-concept. Pharm Dev Technol 2012;17:285-302.
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Published
2024-01-20
How to Cite
Maloth Ravi ,Dr Garima Gupta,Dr.B.Ramu. (2024). Advancing Oral Drug Delivery of BCS Class II Drugs Using Solid Lipid Nanoparticles. Journal of Computational Analysis and Applications (JoCAAA), 32(1), 1522–1534. Retrieved from https://eudoxuspress.com/index.php/pub/article/view/5769
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