Architecting Buffer and SMCC Skid Automation Through ISA-88 Architecture: A Practical Implementation Framework

Authors

  • Prashant Mavani

Keywords:

Isa-88 Architecture, Sequential Multi-Column Chromatography, Inline Buffer Formulation, Pharmaceutical Automation, Manufacturing Execution Systems

Abstract

Problem Statement: Biopharmaceutical manufacturers face critical challenges in downstream processingautomation where Sequential Multi-Column Chromatography (SMCC) and Inline Buffer Formulation(IBF) systems operate in semi-continuous modes that defy traditional discrete batch control paradigms. Existing automation approaches either force-fit continuous

References

Kevin Gibson, et al., "Evaluation of the Impact of Buffer Management Strategies on Biopharmaceutical Manufacturing Process Mass Intensity," MDPI, 2023. [Online]. Available: https://www.mdpi.com/2227-9717/11/8/2242

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Published

2026-03-09

How to Cite

Prashant Mavani. (2026). Architecting Buffer and SMCC Skid Automation Through ISA-88 Architecture: A Practical Implementation Framework. Journal of Computational Analysis and Applications (JoCAAA), 35(3), 56–90. Retrieved from https://eudoxuspress.com/index.php/pub/article/view/5074

Issue

Vol. 35 No. 3 (2026): JOCAAA

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.