Diosmin as a Hepatoprotective Flavonoid: Mechanistic Insights into Its  Antioxidant and Anti-Inflammatory Protection Against Atorvastatin-Induced  Hepatotoxicity

Esraa Mohamed Mahmoud Abdelhamid, Mohamed Elsayed Kelany, Esraa Yehia Seddik  Elsayed, Doaa M Abdullah

Diosmin as a Hepatoprotective Flavonoid: Mechanistic Insights into Its Antioxidant and Anti-Inflammatory Protection Against Atorvastatin-Induced Hepatotoxicity

Authors

Esraa Mohamed Mahmoud Abdelhamid, Mohamed Elsayed Kelany, Esraa Yehia Seddik Elsayed, Doaa M Abdullah

Keywords:

Diosmin, Hepatoprotective Flavonoid, Atorvastatin-Induced hepatotoxicity

Abstract

Background: Atorvastatin, a widely prescribed lipid-lowering agent, has been associated with idiosyncratichepatotoxicity in susceptible individuals despite its favorable cardiovascular benefits. The hepatotoxic effects ofatorvastatin are largely attributed to oxidative stress, mitochondrial dysfunction, and inflammatory cascades triggered by excessive

References

Jose J. Statins and its hepatic effects: Newer data, implications, and changing recommendations. J Pharm Bioallied Sci. 2016;8(1):23-28.

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Published

2024-05-20

How to Cite

Esraa Mohamed Mahmoud Abdelhamid, Mohamed Elsayed Kelany, Esraa Yehia Seddik Elsayed, Doaa M Abdullah. (2024). Diosmin as a Hepatoprotective Flavonoid: Mechanistic Insights into Its Antioxidant and Anti-Inflammatory Protection Against Atorvastatin-Induced Hepatotoxicity. Journal of Computational Analysis and Applications (JoCAAA), 33(06), 3548–3562. Retrieved from https://eudoxuspress.com/index.php/pub/article/view/4033