Dickkopf-1 in Rheumatoid Arthritis: A Novel Indicator of Inflammation, Bone Destruction, and Disability

Authors

  • Mohammad Hassan Elgawish, Amany M. Ebaid, Ola Ahmed Mohamed El Gehgah, Marwa Abdel Monem Ateya

Keywords:

Dickkopf-1, Rheumatoid Arthritis, Disability

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovitis, systemic inflammation,
and progressive joint destruction, leading to functional disability and decreased quality of life. A key feature of RA is the
imbalance between bone formation and resorption, primarily driven by pro-inflammatory cytokines and dysregulated
signaling pathways. Among these, the Wnt/β-catenin signaling pathway plays a crucial role in bone metabolism. Dickkopf
1 (DKK-1), a secreted glycoprotein and a natural inhibitor of this pathway

References

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Frazzei G, Musters A, de Vries N, van de Stadt L, Gerlag D, van Baarsen L. Prevention of rheumatoid arthritis: a systematic literature review of preventive strategies in at-risk individuals. Autoimmun Rev. 2023;22(1):103217.

Radu A, Bungau S. Management of rheumatoid arthritis: an overview. Cells. 2021;10(11):2857.

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Published

2024-06-17

How to Cite

Mohammad Hassan Elgawish, Amany M. Ebaid, Ola Ahmed Mohamed El Gehgah, Marwa Abdel Monem Ateya. (2024). Dickkopf-1 in Rheumatoid Arthritis: A Novel Indicator of Inflammation, Bone Destruction, and Disability. Journal of Computational Analysis and Applications (JoCAAA), 33(06), 1695–1704. Retrieved from https://eudoxuspress.com/index.php/pub/article/view/2433

Issue

Vol. 33 No. 06 (2024): JOCAAA

Section

Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.