Emerging Genetic Mechanisms of Linezolid Resistance in Enterococci

Authors

  • Somia Mohammed Ali El-Sheikh, Asmaa Ismail Abd-Elwahab Mansour, Zeinab Saed Mohamed Ibrahim

Keywords:

Enterococcus faecalis, Enterococcus faecium, linezolid resistance, optrA, poxtA, cfr, 23S rRNA mutations, antibiotic resistance genes, mobile genetic elements.

Abstract

The emergence of linezolid-resistant enterococci (LRE) represents a significant threat to public health,
especially in hospital settings where vancomycin-resistant enterococci (VRE) already pose major treatment challenges.
Linezolid, a synthetic oxazolidinone antibiotic

References

Bai B, Hu K, Zeng J, et al. Linezolid consumption facilitates the development of linezolid resistance in Enterococcus faecalis in a tertiary-care hospital: a 5-year surveillance study. Microb Drug Resist. 2019;25(6):791798.

Mendes RE, Deshpande LM, Jones RN. Linezolid update: stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms. Drug Resist Updat. 2014;17(1-2):1-12.

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Published

2024-12-26

How to Cite

Somia Mohammed Ali El-Sheikh, Asmaa Ismail Abd-Elwahab Mansour, Zeinab Saed Mohamed Ibrahim. (2024). Emerging Genetic Mechanisms of Linezolid Resistance in Enterococci . Journal of Computational Analysis and Applications (JoCAAA), 33(06), 1676–1684. Retrieved from https://eudoxuspress.com/index.php/pub/article/view/2424

Issue

Vol. 33 No. 06 (2024): JOCAAA

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.