Pathology of Pregnancy in Mothers Is a Risk Factor for the Development of Alport Syndrome in Children

Abstract

In order to study the influence of maternal pregnancy pathology on the development of Alport syndrome in children, the data of 168 case histories of children aged 1 to 14 years with a diagnosis of glomerulonephritis (acute-130 and chronic-38) for 2017-2021, who received inpatient treatment at the children's multidisciplinary clinic of ASMI, were analyzed. It was revealed that the course of Alport syndrome in children has the following clinical and geneological features: the incidence ratio in boys and girls is 3:1, the maximum incidence rate is 6-10 and 11-14 years. These signs are considered criteria for identifying such patients. The occurrence of Alport syndrome in children depends on the age of the mother and the pathology of the pregnancy period (toxicosis of pregnant women, complications of childbirth, renal, cardiovascular and endocrine diseases), consanguineous marriage, concomitant diseases in the child (acute and chronic pyelonephritis, metabolic nephropathy) and the incidence of the child (4-6 times) during the year. These indicators serve as a factor in the early diagnosis of the progression of renal insufficiency in such patients. Dysembriogenetic stigmas in Alport syndrome in children: flattened occiput, pronounced brow arches, hypertelorism of the eyes and nipples, Gothic palate, anomalies of the location of the ears, sandal-shaped gap between 1-2 fingers of the hands and feet, chest deformity and clinodactyly have a high frequency of registration and are considered criteria for clinical diagnosis.