Thermoplastic Polyurethane/Plavix Electrospun Saffolds for Vascular Grafts Application

Abstract

Synthetic vascular grafts with a tiny diameter are particularly vulnerable to thrombosis when utilized for bypass treatments. One promising option for addressing this unmet clinical need is the research and development of bioresorbable vascular scaffolds that can release antithrombotic drugs locally and over a prolonged period within the vascular lumen. To achieve this goal, we present the development and characterization of aPlavix -loaded electrospun Thermoplastic Polyurethane (TPU) scaffold for vascular grafts. Three aspirin dosages were investigated (0.2, 0.6, 1) % from Plavix value. All of the platforms had a fibrous structure. Measurement of theViscosity-Shear Rate Relationship,Surface Tension, Electrical Conductivity, contact angle, Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (FESEM), atomic force microscopy (AFM), were used to complete the characterization. In addition, Blood compatibility of the final nanofibers was evaluated using the activated partial thromboplastin time APTT and partial thromboplastin time PT,As a result of the viscosity of the samples decreased with increasing Plavix concentration and also with an increasing shear ratefor TPU/Plavix, the surface tension increased with increment of the cohesiveness. For the contact angle test, the produced nanofiber is hydrophilic. TPU and Plavix form a hydrogen bond, and the FTIR demonstrates this interaction. In contrast to the pure TPU control, the FESEM examination of the manufactured scaffolds revealed a random morphology of nanofibers. Using AFM analysis, we showed that the surface smoothness of nanofibers was elevated in comparison to the control. Results from activated partial thromboplastin time (APTT) and partial thromboplastin time (PT) assays showed that the manufactured scaffolds were anticoagulant by delaying the activation of a clot. In this study, researchers hypothesized that recently created nanofibers would precisely match desirable vascular graft application features.