Estimating the effectiveness of the enzyme lipase and some life variables in patients with hypothyroidism associated with hyperlipidemia

Abstract

Hypothyroidism is a widespread disease all over the world and occurs as a result of a defect in the mechanism of the thyroid gland or in the work of the gland itself, where the level of its hormones in the blood decreases. The cause of this imbalance may be the lack of production of thyroid-stimulating hormone from the pituitary gland, damage to thyroid cells, or an autoimmune disease that leads to partial or complete damage to thyroid cells, which causes a lack of thyroid hormones in the blood, where This leads to slow metabolism of fats and carbohydrates and a direct negative impact on the rest of the body organs and tissues such as the pancreas, brain, heart and liver and has a clear impact on the growth process. One of the most important effects of hypothyroidism that has currently been studied is a significant rise in blood lipids, as well as the effect of thyroid hormones on the work of the enzyme lipase is clear, as there is an increase in the enzyme lipase in the blood serum with a clear delay in lipolysis, in addition to the high level of triglycerides, cholesterol, LDL, VLDL, and a disorder in HDL. In this study, the level of thyroid-stimulating hormone and the presidential hormones secreted by the thyroid gland thyroid thyroid thyronine triiodine and thyroxine were evaluated, as well as the measurement of The level of the enzymeLipin G, measuring the level of lipids, determining the relationship between them, and determining the correlation between the enzyme Lipase and some other variables. Where these variables were measured for 90 samples, 60 samples diagnosed by the doctor as having hypothyroidism associated with hyperlipidemia and 30 samples from healthy people. The measurements were carried out in the specialized laboratories for pathological analysis in Mosul city, Iraq. The study found that there was an increase in the level of thyroid-stimulating hormone compared to the control group. A decrease in the level of triiodine threonine and thyroxine compared to the control group in addition to a high level of lipi G enzyme compared to the control group in addition to a high level of triglycerides, cholesterol, very low density protein, low-density lipoprotein and a disorder in the level of high-density lipoprotein as was conducted in this study linear correlation relations between the enzyme lipase and the rest of the biochemical variables, where there was a positive linear correlation between the enzyme  lipase and T3 T4, triglycerides, VLDL and a negative linear correlation between lipase enzyme, TSH, cholesterol, HDL and LDL.